Chemoselective enrichment for natural products discovery
نویسندگان
چکیده
منابع مشابه
Chemoselective enrichment for natural products discovery.
Natural products account for a significant proportion of modern day therapeutic agents. However, the discovery of novel compounds is hindered by the isolation process, which often relies upon extraction and chromatographic separation techniques. These methods, which are dependent upon the physicochemical properties of the compounds, have a limited ability to both purify and concentrate the mino...
متن کاملNatural products and drug discovery
The medicinal use of natural products—compounds that are derived from natural sources such as plants, animals or micro-organisms—precedes recorded human history probably by thousands of years. Palaeoanthropological studies at the cave site of Shanidar, located in the Zagros Mountains of Kurdistan in Iraq, have suggested that more than 60,000 years ago, Neanderthals might have been aware of the ...
متن کاملNextGen microbial natural products discovery
Small-molecule secondary metabolites isolated from microorganisms and plants provide the chemical scaffolds of a large fraction of today’s pharmaceuticals. Evolutionary forces shaped the molecular complexity of these natural products that contribute to the exquisite binding of these compounds to biological targets. Starting with the discovery of penicillin by Fleming, we have seen a rapid incre...
متن کاملNatural products in drug discovery.
Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer agents and anti-infectives. Application of molecular biological techniques is increasing the availability of novel compounds that can be conveniently produced in bacteria or yeasts, and combinatorial chemistry approa...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2011
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c0sc00620c